The only RNA molecules known to be branched are circular structures with tails known as lariats that arise during nuclear pre‐mRNA splicing. Lariats accumulate within a large multicomponent particle called a spliceosome that forms upon the addition of unspliced mRNA to nuclear extracts. Recently an RNA molecule has been observed to catalyze branch formation. In this case a single intron of a yeast mitochondrial pre‐mRNA participates in a self‐splicing reaction that results in the accumulation of branched lariats that are processed (...) to correctly spliced exons.An enzyme highly specific for branch removal found in the same extracts that form branches during pre‐mRNA splicing can debranch RNA lariats to their linear forms without loss of nucleotides.The chemical synthesis of branched RNA has recently been achieved. High yields of sequence‐specific oligonucleotides are now available for the analysis of RNA splicing by techniques dependent on branch‐site recognition. (shrink)

Throughout the twentieth century calls to modernize natural history motivated a range of responses. It was unclear how research in natural history museums would participate in the significant technological and conceptual changes that were occurring in the life sciences. By the 1960s, the Museum of Vertebrate Zoology at the University of California, Berkeley, was among the few university-based natural history museums that were able to maintain their specimen collections and support active research. The MVZ therefore provides a window to the (...) modernization of natural history. This paper concentrates on the directorial transitions that occurred at the MVZ between 1965 and 1971. During this period, the MVZ had four directors: Alden H. Miller (Director 1940–1965), an ornithologist; Aldo Starker Leopold (Acting Director 1965–1966), a conservationist and wildlife biologist; Oliver P. Pearson (Director 1966–1971), a physiologist and mammalogist; and David B. Wake (Director 1971–1998), a morphologist, developmental biologist, and herpetologist. The paper explores how a diversity of overlapping modernization strategies, including hiring new faculty, building infrastructure to study live animals, establishing new kinds of collections, and building modern laboratories combined to maintain collections at the MVZ’s core. The paper examines the tensions between the different modernization strategies to inform an analysis of how and why some changes were institutionalized while others were short-lived. By exploring the modernization of collections-based research, this paper emphasizes the importance of collections in the transformation of the life sciences. (shrink)

L’écrivain Edmond Jabès , d’abord de nationalité italienne en Egypte puis de nationalité française en France et de langue française, était d’origine juive. Ecrivain libre et solitaire, loin des partis et des groupes littéraires, la prise de conscience de sa judéïté marqua cette dimension littéraire, sans être réductible à cette judéïté. Héritière d’une tradition liée aux diverses interrogations sur Dieu, le désert, le silence et les textes millénaires, porteuse par sa modernité, de la question d’un « Judaïsme après Dieu (...) », l’œuvre de Jabès est également questionnement sur ce qui conduira le peuple juif de l’Exil à la Shoah et de la Shoah à la création de l’Etat d’Israël. J.-M. Sauvage tente dans cet article de comprendre et d’interpréter l’approche qu’a fait Jabès de cette question difficile et fondamentale : qu’est-ce qu’être juif lorsqu’on est juif athée en diaspora ?The writer Edmond Jabès , at first of Italian nationality in Egypt, then of French nationality in France and French-speaking, was of Jewish origin. A free and solitary writer who was far removed from literary parties and groups, the awareness of his Jewishness would mark this literary dimension without being reducible to this Jewishness. Heir of a tradition tied to diverse questions about God, the desert, silence, and millennial texts, carried by his modernity, of the question of a “Judaism after God,” the work of Jabès is equally a questioning of that which would lead the Jewish people from the Exile to the Shoah and from the Shoah to the creation of the State of Israel. In this article J.-M. Sauvage attempts to understand and interpret the approach that Jabès made to this difficult and fundamental question : what is it to be a Jew when one is an atheistic Jew in the Diaspora ? (shrink)

Both individually and as a collection, these essays will promote understanding and provoke further debate amongst students and established scholars alike.

On 25th October 1946, in a crowded room in Cambridge, Ludwig Wittgenstein and Karl Popper came face to face for the first and only time. The meeting was a disaster, their loud and aggressive confrontation became the stuff of legend. This book tells what really went on in that room.

When first published twenty years ago, The Logic of Medicine presented a new way of thinking about clinical medicine as a scholarly discipline as well as a profession. Since then, advances in research and technology have revolutionized both the practice and theory of medicine. In this new, extensively rewritten edition, Dr. Murphy includes changes to show how these different areas of scholarship may affect details of "the logic of medicine" without compromising its fundamental coherence. New to this edition are discussions (...) of the challenge of the flood of new empirical data, new ideas in genetics, molecular biology, homeostasis, pathogenesis, cancer, aging, and Alzheimer's disease. Murphy also comments on such new theoretical topics as dynamic systems, chaos, and fractals and their impact on the burgeoning fields of philosophy and practice of medicine. Written with medical students in mind, the book includes a glossary, many new examples, and problems for solutions with comments on each. An entirely new chapter deals with modeling. Clinicians and researchers will also find the principles thought-provoking and illuminating. (shrink)

La 4e de couverture indique : "Cet ouvrage est écrit à quatre mains et porte sur la relation entre création artistique et sciences de la cognition. L'ouvrage propose deux approches de l'expérience esthétique. Une approche en troisième personne mobilisant des modèles propres aux systèmes dits auto-organisateurs issus de la biologie dédiée à la réception des œuvres d'art et une approche en première personne rendant compte par auto-analyse d'une pratique artistique vécue qui s'appuie également sur de tels systèmes, systèmes eux-mêmes liés (...) aux concepts d'émergence et de complexité". (shrink)

Keine ausführliche Beschreibung für "Reform der Wissenschaften, zur Herstellung der Einheit zwischen Theorie und Praxis, Teil 1" verfügbar.

There are many algorithm texts that provide lots of well-polished code and proofs of correctness. Instead, this book presents insights, notations, and analogies to help the novice describe and think about algorithms like an expert. By looking at both the big picture and easy step-by-step methods for developing algorithms, the author helps students avoid the common pitfalls. He stresses paradigms such as loop invariants and recursion to unify a huge range of algorithms into a few meta-algorithms. Part of the goal (...) is to teach the students to think abstractly. Without getting bogged with formal proofs, the book fosters a deeper understanding of how and why each algorithm works. These insights are presented in a slow and clear manner accessible to second- or third-year students of computer science, preparing them to find their own innovative ways to solve problems. (shrink)

Contemporary approaches to adolescent development are framed by positive youth development models. A key outcome of these models is that healthy and positively developing youth are more likely to contribute to their family, schools, and communities. However, little work on contribution and its antecedents has been conducted with youth of color. As high achieving youth of color often become leaders in their communities, it is important to consider malleable predictors of contribution within this population. Therefore, through a cross-sectional design, we (...) examined the relations between youth critical reflection, hopeful future expectations, and mentoring relationship quality and youth contribution in a sample of 177 youth of color (60% Black, 40% Latinx) attending an afterschool college preparation program at six sites around the U.S. Results indicated that youth critical reflection, hopeful future expectations, and mentoring relationship quality significantly predicted contribution. Exploratory analyses suggested that these relations were significant for Black youth but not Latinx youth. Implications of these findings for future scholarship are discussed. (shrink)

Consciousness and Qualia is a philosophical study of qualitative consciousness, characteristic examples of which are pains, experienced colors, sounds, etc.

This book reflects upon the manner in which medical research is performed and interpreted.

In order to contribute to the consolidation in the field ofPositive Psychology, we reinvestigated the factor structure of top 10 positive emotions of Barbara Fredrickson. Former research in experimental settings resulted in a three-cluster solution, which we tested withexploratoryandconfirmatorymethodology against different factor models. Within our non-experimental data (N= 312), statistical evidence is presented, advocating for a single factor model of the 10 positive emotions. Different possible reasons for the deviating results are discussed, as well as the theoretical significance to various (...) subfields inPositive Psychology(e.g., therapeutical interventions). Furthermore, the special role ofawewithin the study and its implications for further research in the field are discussed. (shrink)

Dans un passage de Physique iii (7, 207b15-21), Aristote s’exprime d’une manière qui suppose valide l’implication suivante : « Si une grandeur peut être infinie en puissance, une telle grandeur peut aussi être infinie en acte ». Cette implication a intrigué les commentateurs tant anciens et médiévaux que modernes. Ces derniers se sont en général bornés à constater que l’implication n’est pas logiquement valide, sans expliquer comment et en quel sens Aristote avait pu la tenir pour telle. En rapprochant le (...) passage précité d’un autre passage de Physique iii (6, 206b16-27), le présent article en propose une interprétation qui semble lever toutes les difficultés. Au Moyen Age, le sens de l’implication a été très discuté, et l’interprétation proposée ici a été vue et soutenue par plusieurs commentateurs : on l’étudie chez quelques-uns de ceux-ci en situant leur position dans le cadre du débat médiéval sur la question, notamment en référence aux deux interprétations alors fameuses proposées par Averroès. (shrink)

Given the apparent nondisplaceability and noncancellability of the derogatory content of slurs, it may appear puzzling that non-derogatory uses of slurs exist. Moreover, these uses seem to be in general available only to in-group speakers, thereby exhibiting a peculiar kind of context-sensitivity. In this paper the author argues that to understand non-derogatory uses we should consider slurs in terms of the kind of social practice their uses instantiate. A suitable theory of social practices has been proposed by McMillan. In typical (...) uses the practice is one of bigotry and discrimination. Non-derogatory uses are only possible to the extent that they consitute acts of an alternative, non-derogatory practice. In the core cases it must be a subversive practice of satire or reappropriation. The social identity of speakers is not an ultimately decisive factor but it is an important constitutive condition: most non-derogatory practices of slur-use can only be performed by a member of the target group. (shrink)

Twenty-seven of today's leading philosophers each introduce and explore ideas from one of history's greatest minds." -- Cover.

Sample quotes from emails sent by visitors to Mary Klages's successful literary theory web pages on which this book is based: 'Finding your course was a godsend ...

Originally published in 1955, The Moral Decision remains today a fresh, lively, and literate quest for moral guides in the American system of law. Each topic is introduced with a real courtroom case followed by a summary of the uncontroverted facts, the issues before the court, the judge's opinion, and Edmond Cahn's objective and penetrating discussion of the ethical issues involved. The cases chosen operate as prisms, revealing an entire spectrum of moral forces—personal ambitions, group standards, lusts, sufferings, and (...) ideals. A new foreword by Norman Redlich, Dean of the New York University School of Law, affirms the value of The Moral Decision as an authoritative and humane introduction to law and morality. (shrink)